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Welcome to the Tang Lab
Our lab is committed to sharing our research and findings with the scientific community. Visit our publications page to view our latest research papers and scientific publications.
Cover Galleries
Selected Publications by Years
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2026
71. Fan, Y., Chang, J., Qin, X., Li, M., Li, Y., Wu, L., Li, K., Chen, Z., Li, Y.,
Tang, Z.*
, Xie, D., & Shi, J. (2026). Copper-Based Targeted Nanocatalytic Therapeutics for Non-Small Cell Lung Cancer.
Nano-Micro Letters
, 18(1), 152. https://doi.org/10.1007/s40820-025-01998-5
70. Fan, Y., Li, M., Li, M., Zhu, S., Li, Y., Qin, X., Chang, J., Li, Y., Wu, L., Li, K., Xie, D.,
Tang, Z.*
, & Shi, J. (2026). Remodeling the immunosuppressive microenvironment of KARS-LKB1 co-mutant non-small cell lung cancer via targeted PGAM5 siRNA delivery for enhanced immunotherapy.
Materials Today
. https://doi.org/https://doi.org/10.1016/j.mattod.2026.01.001
2025
69. Zhao, R., Zhu, Y.,
Tang, Z.
, Lin, H., & Shi, J. (2025). Modulation of electron transfer properties in two-dimensional nanomaterials for enhanced therapeutic efficacy.
Nano Today
, 65, 102880. https://doi.org/https://doi.org/10.1016/j.nantod.2025.102880
68. Li, Y., Fan, Y., Yang, H., Chang, J., Li, M., Peng, F., Xie, D., &
Tang, Z.*
(2025). Nanotechnology applications in the regulation of metabolic diseases.
Coordination Chemistry Reviews
, 538, 216736. https://doi.org/https://doi.org/10.1016/j.ccr.2025.216736
67. Li, M., Huo, Q., &
Tang, Z.
(2025). Harnessing smart nanomaterials to redefine diagnostics and therapy for critical diseases.
Coordination Chemistry Reviews
, 544, 216991. https://doi.org/https://doi.org/10.1016/j.ccr.2025.216991
66.
Jiang, L., Wu, T., Qu, X., Li, S., Jiang, Q. a., Ren, T., Liang, J., Ding, Y., Hua, K.,
Tang, Z.*
, & Qiu, J. (2025). Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer.
Journal of Nanobiotechnology
, 23(1), 413. https://doi.org/10.1186/s12951-025-03500-0
65. Zheng, G.,
Tang, Z.*
, & Peng, F. (2025). Ultrasound-activated inorganic nanomaterials to generate ROS for antibacterial applications [10.1039/D5BM00121H].
Biomaterials Science
, 13(10), 2628–2641. https://doi.org/10.1039/D5BM00121H
64. Liu, Z., Yao, Z., Yang, H., Wu, S., &
Tang, Z.*
(2025). Leveraging the dual role of ROS in liver diseases with nanomaterials: clearing and amplifying for therapy [10.1039/D4NR04469J].
Nanoscale
, 17(7), 3688–3697. https://doi.org/10.1039/D4NR04469J
2024
63. Wu, S., Xu, T., Gao, J., Zhang, Q., Huang, Y., Liu, Z., Hao, X., Yao, Z., hao, X., Wu, P.-Y., Wu, Y., Yin, B., &
Tang, Z.*
(2024). Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles.
European Journal of Nuclear Medicine and Molecular Imaging
, 52(1), 48–61. https://doi.org/10.1007/s00259-024-06894-5
62. Xiao, Y.,
Tang, Z.
, Zhang, J., Saiding, Q., Li, Y., Du, J., & Tao, W. (2024). One-Pot Synthesis of Fe-Norepinephrine Nanoparticles for Synergetic Thermal-Enhanced Chemodynamic Therapy.
Nano Letters
, 24(43), 13825–13833. https://doi.org/10.1021/acs.nanolett.4c04375
61. Liu, F., Yang, J., Zhang, J., Wong, N.,
Tang, Z.
, & Cai, W. (2024). Development of 177Lu-FL-091 for the treatment of NTSR1-positive cancers.
Journal of Nuclear Medicine
, 65(supplement 2), 241875–241875.
60.
Tang, Z.
, Yu, F., Hsu, J. C., Shi, J., & Cai, W. (2024). Soybean Oil-Derived Lipids for Efficient mRNA Delivery.
Advanced Materials
, 36(13), 2302901. https://doi.org/https://doi.org/10.1002/adma.202302901
59. Malih, S., Lin, W.,
Tang, Z.
, DeLuca, M. C., Engle, J. W., Alirezapour, B., Cai, W., & Rasaee, M. J. (2024). Noninvasive PET imaging of tumor PD-L1 expression with (64)Cu-labeled Durvalumab.
Am J Nucl Med Mol Imaging
, 14(1), 31–40. https://doi.org/10.62347/huqd8000
2023
58. Li, L., Shen, Y.,
Tang, Z.
, Yang, Y., Fu, Z., Ni, D., & Cai, X. (2023). Engineered nanodrug targeting oxidative stress for treatment of acute kidney injury.
Exploration
, 3(6), 20220148. https://doi.org/https://doi.org/10.1002/EXP.20220148
57. Yan, J.,
Tang, Z.
, Li, Y., Wang, H., Hsu, J. C., Shi, M., Fu, Z., Ji, X., Cai, W., Ni, D., & Qu, J. (2023). Molybdenum Nanodots for Acute Lung Injury Therapy.
ACS Nano
, 17(23), 23872–23888. https://doi.org/10.1021/acsnano.3c08147
56. Silva Pedraza, Z., Wang, Y., Carlos, C.,
Tang, Z.
, Li, J., Cai, W., & Wang, X. (2023). Development of Ferroelectric P(VDF-TrFE) Microparticles for Ultrasound-Driven Cancer Cell Killing.
ACS Appl Mater Interfaces
, 15(47), 54304–54311. https://doi.org/10.1021/acsami.3c13410
55.
Tang, Z.
, You, X., Xiao, Y., Chen, W., Li, Y., Huang, X., Liu, H., Xiao, F., Liu, C., Koo, S., Kong, N., & Tao, W. (2023). Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection.
Proceedings of the National Academy of Sciences
, 120(44), e2304966120. https://doi.org/doi:10.1073/pnas.2304966120
54. Lin, Z., Chen, Z., Chen, Y., Yang, N., Shi, J.,
Tang, Z.
, Zhang, C., Lin, H., & Yin, J. (2023). Hydrogenated silicene nanosheet functionalized scaffold enables immuno-bone remodeling.
Exploration
, 3(4), 20220149. https://doi.org/https://doi.org/10.1002/EXP.20220149 (
Front Cover Paper
)
53. Hsu, J.,
Tang, Z.
, & Cai, W. (2023). “Chemical factory”-guaranteed chemodynamic therapy of orthotopic liver cancer.
Journal of Nuclear Medicine
, 64(supplement 1), P219.
52. Liu, H.-J., Chen, W., Wu, G., Zhou, J., Liu, C.,
Tang, Z.
, Huang, X., Gao, J., Xiao, Y., Kong, N., Joshi, N., Cao, Y., Abdi, R., & Tao, W. (2023). Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects.
Advanced Science
, 10(16), 2207439. https://doi.org/https://doi.org/10.1002/advs.202207439
51. Hsu, J. C.,
Tang, Z.
, Eremina, O. E., Sofias, A. M., Lammers, T., Lovell, J. F., Zavaleta, C., Cai, W., & Cormode, D. P. (2023). Nanomaterial-based contrast agents.
Nature Reviews Methods Primers
, 3(1), 30. https://doi.org/10.1038/s43586-023-00211-4
50. Guo, J., Zhao, Z., Shang, Z.-F.,
Tang, Z.
, Zhu, H., & Zhang, K. (2023). Nanodrugs with intrinsic radioprotective exertion: Turning the double-edged sword into a single-edged knife.
Exploration
, 3(2), 20220119. https://doi.org/https://doi.org/10.1002/EXP.20220119
49. Ji, X.,
Tang, Z.
, Liu, H., Kang, Y., Chen, L., Dong, J., Chen, W., Kong, N., Tao, W., & Xie, T. (2023). Nanoheterojunction-Mediated Thermoelectric Strategy for Cancer Surgical Adjuvant Treatment and β-Elemene Combination Therapy.
Advanced Materials
, 35(8), 2207391. https://doi.org/https://doi.org/10.1002/adma.202207391
2022
48. Younis, M. H.,
Tang, Z.*
, & Cai, W. (2022). Multimodality imaging of nanoparticle-based vaccines: Shedding light on immunology.
WIREs Nanomedicine and Nanobiotechnology
, 14(5), e1807. https://doi.org/https://doi.org/10.1002/wnan.1807
47.
Tang, Z.
, Wu, S., Zhao, P., Wang, H., Ni, D., Li, H., Jiang, X., Wu, Y., Meng, Y., Yao, Z., Cai, W., & Bu, W. (2022). Chemical Factory-Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer.
Advanced Science
, 9(23), 2201232. https://doi.org/https://doi.org/10.1002/advs.202201232
46. Feng, C., Li, Y., Ferdows, B. E., Patel, D. N., Ouyang, J.,
Tang, Z.
, Kong, N., Chen, E., & Tao, W. (2022). Emerging vaccine nanotechnology: From defense against infection to sniping cancer.
Acta Pharmaceutica Sinica B
, 12(5), 2206–2223. https://doi.org/https://doi.org/10.1016/j.apsb.2021.12.021
45. Xu, L., Sun, Z., Xing, Z., Liu, Y., Zhao, H.,
Tang, Z.
, Luo, Y., Hao, S., & Li, K. (2022). Cur@SF NPs alleviate Friedreich’s ataxia in a mouse model through synergistic iron chelation and antioxidation.
Journal of Nanobiotechnology
, 20(1), 118. https://doi.org/10.1186/s12951-022-01333-9
44. Xiao, Y.,
Tang, Z.
(
Co-first
)
, Huang, X., Chen, W., Zhou, J., Liu, H., Liu, C., Kong, N., & Tao, W. (2022). Emerging mRNA technologies: delivery strategies and biomedical applications [10.1039/D1CS00617G]. Chemical Society Reviews, 51(10), 3828–3845. https://doi.org/10.1039/D1CS00617G(
Front Cover Paper
)
2021
43. Ouyang, J., Zhang, L., Li, L., Chen, W.,
Tang, Z.
, Ji, X., Feng, C., Tao, N., Kong, N., Chen, T., Liu, Y.-N., & Tao, W. (2021). Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics.
Nano-Micro Letters
, 13(1), 90. https://doi.org/10.1007/s40820-021-00619-1
42.
Tang, Z.
, Xiao, Y., Kong, N., Liu, C., Chen, W., Huang, X., Xu, D., Ouyang, J., Feng, C., Wang, C., Wang, J., Zhang, H., & Tao, W. (2021). Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy.
Acta Pharmaceutica Sinica B
, 11(11), 3447–3464. https://doi.org/https://doi.org/10.1016/j.apsb.2021.05.004
41. Huang, X., Wu, G., Liu, C., Hua, X.,
Tang, Z.
, Xiao, Y., Chen, W., Zhou, J., Kong, N., Huang, P., Shi, J., & Tao, W. (2021). Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy.
Nano Letters
, 21(22), 9706–9714. https://doi.org/10.1021/acs.nanolett.1c03539
40. Xiao, Y.,
Tang, Z.
, Huang, X., Joseph, J., Chen, W., Liu, C., Zhou, J., Kong, N., Joshi, N., Du, J., & Tao, W. (2021). Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes.
Matter
, 4(10), 3269–3285. https://doi.org/10.1016/j.matt.2021.08.011
39. Liu, C., Sun, S., Feng, Q., Wu, G., Wu, Y., Kong, N., Yu, Z., Yao, J., Zhang, X., Chen, W.,
Tang, Z.
, Xiao, Y., Huang, X., Lv, A., Yao, C., Cheng, H., Wu, A., Xie, T., & Tao, W. (2021). Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy.
Advanced Materials
, 33(37), 2102054. https://doi.org/https://doi.org/10.1002/adma.202102054
38. Wang, L., Dai, C., Jiang, L., Tong, G., Xiong, Y., Khan, K.,
Tang, Z.
, Chen, X., & Zeng, H. (2021). Advanced Devices for Tumor Diagnosis and Therapy.
Small
, 17(28), 2100003. https://doi.org/https://doi.org/10.1002/smll.202100003
37. You, Y.,
Tang, Z.*
, Lin, H., & Shi, J. (2021). Emerging two-dimensional material nanozymes for theranostic nanomedicine.
Biophysics Reports
, 7(3), 159–172. https://doi.org/10.52601/bpr.2021.210011
36. Zhao, P., Jiang, Y.,
Tang, Z.*
, Li, Y., Sun, B., Wu, Y., Wu, J., Liu, Y., & Bu, W. (2021). Constructing Electron Levers in Perovskite Nanocrystals to Regulate the Local Electron Density for Intensive Chemodynamic Therapy.
Angewandte Chemie International Edition
, 60(16), 8905–8912. https://doi.org/https://doi.org/10.1002/anie.202100864
35. Zhang, X., Duan, X., Hu, Y.,
Tang, Z.
, Miao, C., Tao, W., & Wu, J. (2021). One-step and facile synthesis of peptide-like poly(melphalan) nanodrug for cancer therapy.
Nano Today
, 37, 101098. https://doi.org/https://doi.org/10.1016/j.nantod.2021.101098
34. Wang, H., Gao, H., Jiang, X., Zhao, P., Ni, D.,
Tang, Z.
, Liu, Y., Zheng, X., & Bu, W. (2021). Regulating water states by vacancies for cancer therapy.
Nano Today
, 37, 101099. https://doi.org/https://doi.org/10.1016/j.nantod.2021.101099
33. Chen, W., Liu, C., Ji, X., Joseph, J.,
Tang, Z.
, Ouyang, J., Xiao, Y., Kong, N., Joshi, N., Farokhzad, O. C., Tao, W., & Xie, T. (2021). Stanene-Based Nanosheets for β-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy.
Angewandte Chemie International Edition
, 60(13), 7155–7164. https://doi.org/https://doi.org/10.1002/anie.202016330
32. Ji, X., Ge, L., Liu, C.,
Tang, Z.
, Xiao, Y., Chen, W., Lei, Z., Gao, W., Blake, S., De, D., Shi, B., Zeng, X., Kong, N., Zhang, X., & Tao, W. (2021). Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics.
Nature Communications
, 12(1), 1124. https://doi.org/10.1038/s41467-021-21436-5
31.
Tang, Z.
, Zhang, X., Shu, Y., Guo, M., Zhang, H., & Tao, W. (2021). Insights from nanotechnology in COVID-19 treatment.
Nano Today
, 36, 101019. https://doi.org/https://doi.org/10.1016/j.nantod.2020.101019
30.
Tang, Z.
, Zhao, P., Wang, H., Liu, Y., & Bu, W. (2021). Biomedicine Meets Fenton Chemistry.
Chemical Reviews
, 121(4), 1981–2019. https://doi.org/10.1021/acs.chemrev.0c00977 (
High-cited paper
)
29. Liu, C., Shin, J., Son, S., Choe, Y., Farokhzad, N.,
Tang, Z.
, Xiao, Y., Kong, N., Xie, T., Kim, J. S., & Tao, W. (2021). Pnictogens in medicinal chemistry: evolution from erstwhile drugs to emerging layered photonic nanomedicine [10.1039/D0CS01175D].
Chemical Society Reviews
, 50(4), 2260–2279. https://doi.org/10.1039/D0CS01175D
28. Wang, L., Xu, D., Jiang, L., Gao, J.,
Tang, Z.
, Xu, Y., Chen, X., & Zhang, H. (2021). Transition Metal Dichalcogenides for Sensing and Oncotherapy: Status, Challenges, and Perspective.
Advanced Functional Materials
, 31(5), 2004408. https://doi.org/https://doi.org/10.1002/adfm.202004408
2020
27. Zhang,
Z., Tang
, Z., Farokhzad, N., Chen, T., & Tao, W. (2020). Sensitive, Rapid, Low-Cost, and Multiplexed COVID-19 Monitoring by the Wireless Telemedicine Platform.
Matter
, 3(6), 1818–1820. https://doi.org/10.1016/j.matt.2020.11.001
26. Lv, B., Zhang, H., Zheng, X., Wang, H., Ge, W., Ren, Y., Tan, Z., Zhang, M.,
Tang, Z.
, Liu, Y., Zhang, L., Wu, Y., Jiang, X., & Bu, W. (2020). Structure-oriented catalytic radiosensitization for cancer radiotherapy.
Nano Today
, 35, 100988. https://doi.org/https://doi.org/10.1016/j.nantod.2020.100988
25. Ouyang, J.,
Tang, Z.
, Farokhzad, N., Kong, N., Kim, N. Y., Feng, C., Blake, S., Xiao, Y., Liu, C., Xie, T., & Tao, W. (2020). Ultrasound mediated therapy: Recent progress and challenges in nanoscience.
Nano Today
, 35, 100949. https://doi.org/https://doi.org/10.1016/j.nantod.2020.100949
24. Ouyang, J., Ji, X., Zhang, X., Feng, C.,
Tang, Z.
, Kong, N., Xie, A., Wang, J., Sui, X., Deng, L., Liu, Y., Kim, J. S., Cao, Y., & Tao, W. (2020). In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment.
Proceedings of the National Academy of Sciences
, 117(46), 28667–28677. https://doi.org/doi:10.1073/pnas.2016268117
(
High-cited paper
)